Changes in immunofunction in fulminant hepatitis.

概要

論文の詳細を見る
The prognosis for fulminant hepatitis (FH) complicated by in-fections is poor with a progressive reduction of host immuno-competency. Im-munological differences were examined in 13 patients who survived FH and 19 patients who died from the disease. Although T cells were at normal levels in those who survived the disease, they were reduced in many of those who died. B cells were markedly reduced both in the survivors and non-survivors. Lym-phocyte function, as evaluated by Con-A stimulation, tended to be greater in the survivors. Lymphocyte subset studies using monoclonal antibodies revealed normal or slightly reduced OKT 11, slightly increased OKT 4, and slightly re-duced OKT 8 and OKIa 1. For B cell subsets, IgG was markedly reduced from normal levels, IgA was slightly reduced, but the IgM level was normal. Im-munoglobulin (IgG, IgA, and IgM) levels were normal in both groups of pa-tients, but were significantly higher in the survivors than in the non-survivors. Transferrin was reduced in both groups; and it decreased significantly (p<0.05) during the hospitalization of the non-survivors. Fibronectin was reduced in both groups on admission, but it increased significantly (p<0.01) in the survivors while it decreased significantly (p<0.05) in those who died during hospitalization.
久留米大学医学部 The Kurume Medical Journal 編集部の論文