Alpha<SUB>2</SUB>-Adrenoceptor Inhibition in Patients with Vibration White Fingers
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概要
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In healthy subjects the physiological vasoconstriction to local cooling has been linked to sympathetic adrenoceptors of the alpha<SUB>2</SUB>-subtype. The present study was designed to determine if the vasoconstriction in response to local cooling in patients suffering from vibration white fingers can be diminished by alpha<SUB>2</SUB>-adrenoceptor inhibition. Six men with vibration white fingers, verified in a cold provocation test, were examined. To study the effect of local skin cooling blood flow was measured with laser doppler technique on the dorsum of dig. II or III. The temperature of the laser doppler probe was regulated by Peltier elements. Temperature could be lowered from 30°C to 20°C within 30s. Measurements were performed before and after local inhibition of the alpha<SUB>2</SUB>-adrenoceptors. This was achieved by the introduction of the selective alpha<SUB>2</SUB>-adrenoceptor inhibitor, rauwolscine, into the finger skin by iontophoresis. During control conditions local cooling consistently resulted in a marked vasoconstriction. Inhibition of the alpha<SUB>2</SUB>-adrenoceptors by rauwolscine completely abolished this effect. The present data indicate that substances inhibiting alpha<SUB>2</SUB>-adrenoceptors may be of therapeutic value in patients with vibration white fingers.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文