Caveolae Localization and Caveolin Expressions in Schwann Cells of Mature Rat Spinal Nerves

スポンサーリンク

概要

• 論文の詳細を見る

• Caveolae are a specific plasmalemmal microdomain which appear as flask-like invaginations and/or vesicles attaching just beneath the plasmalemma. Caveolae are present in many cell types and are found in the Schwann cells that ensheath myelinated and unmyelinated nerve fibers of the peripheral nervous tissues. However, the precise distribution in the Schwann cell plasmalemma and the functional properties of these caveolae remains obscure. The present study revealed:(1) Caveolae are most commonly observed in the Schwann cell plasmalemma of myelinated nerve fibers.(2) Caveolae are principally located in the perikaryal plasmalemma of Schwann cells of the myelinated nerves.(3) Caveolin-1 is expressed strongly in Schwann cell caveolae.(4) Caveolin 2 and 3 are also immunohistochemically detected in Schwann cell caveolae, although the immunoreactivities are slight. The results suggested that caveolae of the peripheral nervous system are involved in cellular activities specific to Schwann cells in myelinated nerve fibers. These caveolae may contain receptors for signaling molecules that could affect the myelinated nerve fibers, and/or proteins related to ion transfer activity. Further studies are necessary in order to clarify the types of proteins associated with Schwann cell caveolae.

• 久留米大学医学部 The Kurume Medical Journal 編集部の論文

著者

• KAWAHARA TARO

  Department of Anatomy & Histology, Kurume University School of Medicine

関連論文

• Regional Diminution of von Willebrand Factor Expression on the Endothelial Covering Arachnoid Granulations of Human, Monkey and Dog Brain.
• Caveolae Localization and Caveolin Expressions in Schwann Cells of Mature Rat Spinal Nerves

スポンサーリンク