腎疾患者における鉄代謝
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概要
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For the purpose of investigating the relation between anemia of renal disease and the iron metabolism, I measured the amount of iron contained in peripheral and bone marrow bloods as well as the iron-binding capacity of serum. From the above and several other experiments, I have obtained the following results:1) It is recognized that the total iron amount in blood has a parallel relation with the number of erythrocytes and the amount of hemoglobin. It is, therefore, obvious that the total amount of iron contained in blood is directly related to anemia.2) The iron amount in serum is not always in a parallel relation with the whole amount of iron in blood. In renal disease, it decreases in general and shows a remarkable diminution especially in nephrotic syndrome and contracted kidney. The iron-binding capacity of serum is also admitted to be in the same inclination.3) The iron amount in serum is not always parallel with the total plasma protein and, furthermore, does not correspond with the extent of anemia.4) No parallel relation is admitted between the pH of serum and its contained iron amount. The iron-binding capacity of serum is alike.5) Iron contained in 0.1cc of bone marrow blood trends to decrease in nephrotic syndrome, which seems to be parallel with the diminution of the number of reticulocytes.6) It is also recognized that, in nephrotic syndrome, a considerable amount of iron combining with protein is excreted in urine.7) It seems, in short, that the severe, or unredeemed anemia in renal disease, especially in nephrotic syndrome, is brought on by the disturbance of blood-forming organs, which is caused by the bad reciprocation of the dysfunction of iron conveyance and utilization and the diminution of the iron amount in body due to the dysfunction of the iron absorption and its remarkable excretion in urine.
- 社団法人 日本内科学会の論文