病巣感染性心炎の成因に關する實驗的研究
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概要
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Based upon Prof. Donomaes concept that the myocardial damage may occur at the early stage of focal infection in its clinical phase, the experiment was undergone to clarify the etiology of myocardial damage produced in focal-infected rabbits, from which the following results were obtained.1) The repeated use of extract of focal lesion and heat-killed Streptococci has successfully produced the experimental carditis presenting the allergic responses simillar to those found in the focal infected rabbits by Aleuronat abscess. Accordingly, adding to the inoculated cocci, one of the significant etiology would be inflammatory products in focal lesion itself.2) Protein fraction in focal lesion is more significant than polysaccharide and phosphatide for the onset of the disease.3) Euglobulin is most significant among the protein fractions in focal lesion, that is, euglobulin, pseudoglobulin and albumin.4) Protein fraction is most signific nt in each fractions being included in hemolytic streptococcus.5) Streptolysin O may promote the disease, while streptokinase not.
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