下垂体並びに副腎皮質ホルモンの細網内皮系機能に及ぼす影響について : 第1編 異種血球處理能よりみたる下垂体副腎皮質ホルモンの細網内皮系機能に及ぼす影響

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概要

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• Though the studies on the relation between pituitary-adrenal hormones and reticuloendothelial system have been reported by several authors, their results do not all agree.The author intended with the present study to determine the influence of these hormones on the function of R. E. S. to manage the hen erythrocytes intravenously injected in rabbits with Ohs method, which indicates the activity of R. E. S. with the endurance of remaining of nuclei in peripheral blood of rabbits after injection of certain quantity of hen erythrocytes.The hormones administered were a single injection of 2.5mg per kg of DOCA, 12.5mg per kg of cortisone intramusculary, 1.5mg per kg of ACTH intravenously, 0.15mg per kg of adrenalin subcutaneously.The results are as follows:1) In animals examined from 12 hours to one week after the injection of DOCA, the nuclei disappeared from the peripheral blood earlier, that is, within 2 hours, than those in normal. This means that R. E. S. function is accelerated by DOCA.2) On the contrary, the function of R. E. S. of animals examined 6 to 12 hours after the injection of Cortisone was apparently depressed. The nuclei remained over 3 hours in peripheral blood.3) In 9 of 11 animals injected with ascorbic acid direct after DOCA, the endurance of the remaining time of nuclei in peripheral blood was normal. It is considered that ascorbic acid inhibits the accelerating effect of DOCA on the R. E. S..4) R. E. S. was accelerated 2 to 12 hours after injection of ACTH, but normal after 24 hours.5) When DOCA and cortisone were injected in the same time in rabbits, the influence of cortisone appeared earlier than DOCA and R. E. S. were depressed till 6 to 12 hours after injection, but after 24 hours the effect of DOCA became dominant and R. E. S. were accelerated. It is considered that these difference of the influence of both hormones is introduced by the difference of the velocity of their resorption and exceretion.6) After the administration of adrenalin no influence on the R. E. S. was seen.7) The inhibiting or accelerating effects of those hormones were not observed in the splenectomized animals. The spleen seems to play an essential rôle to manage the heterogenous blood cells in the animals.

• 社団法人 日本内科学会の論文

著者

• 井關 敏之

  大阪市立大学医学部内科

関連論文

• 下垂体並びに副腎皮質ホルモンの細網内皮系機能に及ぼす影響について : 第1編 異種血球處理能よりみたる下垂体副腎皮質ホルモンの細網内皮系機能に及ぼす影響
• 下垂体-副腎ホルモンの肝及び脾に及ぼす影響特にその病理組織學的所見 : 下垂体並びに副腎ホルモンの細網内皮機能に及ぼす影響第2編

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