腸管内菌叢の交代に關する臨床的研究
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概要
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The alternation of the fecal flora by the administration of several antibiotics, “Aurofac”, lactbacilli and various diet in 102 cases has been studied in this report. The distribution of intestinal flora has also been examined using Miller-Abott tube in 10 cases. The following results were obtained.(1) Medicamentous doses of several antibiotics were administrated in 66 cases (20 cases of healthy persons and 46 cases of patients).In 58 cases in which were administrated AM, TM, CM and SM orally, coli-aerogenes group in the fecal flora was reduced remarkably in number or disappeared completely during the administration of these antibiotics and the species of proteus and pseudomonas became predominant alternatevily.The alternative increase of proteus and pseudomonas species was especially remarkably by the administration of AM and TM but was not so much by the administration of CM and SM.(2) It has been examined whether or not the causative organisms of the infection in the neighbouring organs of the intestine alternate in parallel with the changes of the intestinal flora. The 8 cases of the infection have been observed in which causative organisms were alternated in the neighbouring organs (Cholecystitis 2 cases, cystitis 6 cases). These infections were caused by the organisms which become predominant in the intestinal flora during the oral administration of antibiotics.(3) Marked change or alternation of the fecal flora was not observed in those who were administered small dose of AM orally.The administration of “Aurofac” or preparation of lactbacilli did not produce marked change in the intestinal flora.(4) Using the Miller-Abotttube, marked ascending phenomenon of the gram-negative bacilli, mainly E. coli, was observed in the patients with achylia ga trica in compared with those with normal acidity of the gastric juice.
- 社団法人 日本内科学会の論文