各種藥物の毛細血管透過性に及ぼす影響に關する研究
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概要
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A pressure of 60 mm Hg was applied on the upper arm for the duration of 15 min. to cause blood stagnation and the fluid filtration and the protein loss before and after the pressure application were measured from the hematocrit values and the plasma protein. Next, various drugs were administered and similar measurements effected, to determine the influence of these drugs upon the permeability of blood capillaries. The results may be summarized as follows;1. Calcium chloride and flavon derivatives caused decrease of permeability by enhancing the density of the interendothelial cement substance of the capillaries.2. Hyaluronidase acts in increasing the capillary permeability, while chondroitin sulfate caused its decrease.3. Benzylimidazoline effects increase, but tetraethyl ammonium bromide does not affect in any way the capillary permeability.4. Kallikrein accentuates the permeability but methyl-androstendiol has little effect. Testosterone, estradiol and progesterone normalize abnormalized capillary permeability. Cortisone and interenin-strong perceptibly depresses an accentuated capillar permeability.5. Upon administration of thyroxine an accentuation of the capillary permeability is observed. This accentuation is normalized with methylthiouracil.
- 社団法人 日本内科学会の論文