Depotinsulinの臨床經驗特に24時間血糖値による比較

概要

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In an attempt to ascertain the behavior of the blood sugar throughout an entire day and to determine the action of P.Z.I., N.P.H. and insulin mixtures, blood sugar determinations were carried out at frequent intervals.When compared under similar conditions of diet and activity, same insulin in same dosage showed similar 24 hours blood sugar curve, and it was found that a single dose of N.P.H. brought similar curve as did a combination of unmodified insulin and P.Z.I. given by not separate injection but mixed in the syringe.P.Z.I. its effect began in the late afternoon, but there was no case of hypoglycemic tendency during the night.N.P.H. its effect indicated a more rapid onset and exerted into the evening and night so that the 24 hours curve was generally lower than P.Z.I.s.In the course of the study the effect of giving various types of insulin indicated better in following order of P.Z.I., N.P.H., combination of unmodified 1 and P.Z.I. 2, combination of unmodified 1/3 or 1/2 and N.P.H. 1.Saving of depotinsulin could be expected in the case of under 10 units reqirement and could not in the more over insulin requirement.Administration of P.Z.I. in the morning before breakfast or bedtime, both showed similar 24 hours blood sugar curve.Diabetes in youth, its blood sugar values altered very much more than the adult so that use of insulin must be considered practically.
社団法人日本内科学会の論文