病巣感染性心炎の豫防に關する實驗的研究
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概要
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In considering the prophylaxis of the focal infection, it is essentially required to exclude the causative factors, thereby revealing the disease, and other various factors responsible for the individual resistance to infection.The experimental studies have been undertaken from the above mentioned clinical view in order to attempt the clarification of the various factors which may preventively affect against the carditis due to the focal infection.The carditis due to the focal infection was experimentally produced by repeated injection of β-haemolytic streptococcus, thereby providing subcutaneous aleuronat abszess at the lateral site of abdomen in rats.The following results were experimentally obtained.1) Removing the aleuronat abszess at the early stage of the disease, the heart of rats has not revealed any appreciable lesion of carditis.2) The injection of anti-histamine drag was not effective against carditis.3) The administration of penicillin or small amounts of cortisone arrested the developement of the carditis.4) The injection of large amounts of cortisone has not arrested the onset of the disease, but incited the bacteriemia.5) Vitamin B1 defficiency or intermittent exposure to cold effect has not promoted the onset of carditis.6) The rats exposed to the cold effect for a long term have easily affected from the carditis.
- 社団法人 日本内科学会の論文