Myocardial Ischemia in Kawasaki Disease Evaluation by Dipyridamole Stress Thallium-201 (Tl-201) Myocardial Imaging and Exercise Stress Test.
スポンサーリンク
概要
- 論文の詳細を見る
The detection of myocardial ischemia is essential for evaluation of patients with Kawasaki disease, especially who have had coronary artery lesions. To evaluate the clinical efficacy of T1-201 single photon emission computed tomography (SPECT) after dipyridamole infusion (maximum dose 0.70 mg/kg) for detecting myocardial ischemia, 44 patients with Kawasaki disease aged 7.7±4.8 years at the study and 10 age matched controls were observed. In the Kawasaki disease group, significant coronary artery stenosis was observed in 14, coronary aneurysm without stenosis in 18, the regression of the coronary aneurysms in 2 and without coronary lesions in 10 patients. In 24 of 44 patients, treadmill exercise stress test was also performed at the same period. Myocardial ischemic changes were observed in 11 patients, all combined with significant coronary artery stenosis. The sensitivity of SPECT for detection of overall coronary stenosis was 79.K0, contrary that of treadmill exercise test was only 33% (p<0.001). Furthermore, among the patients having significant coronary stenosis, the severity score was significantly elevated in patients who had electrocardiographic abnormal Q wave compared to those without abnormal Q wave (51.0±38.8 versus 20.0±12.1, p<0.05). These data suggest that the pharmacological stress scintigraphy using dipyridamole injection provides not only the accurate detection but quantitative evaluation of myocardial ischemia in these patients. This noninvasive technique may become one of the most useful index for detection and follow-up of myocardial ischemia in Kawasaki disease.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
関連論文
- MYOCARDIAL ISCHEMIA IN KAWASAKI DISEASE : EVALUATION BY DIPYRIDAMOLE STRESS THALLIUM-201(Tl-201)MYOCARDIAL IMAGING
- INTRAVASCULAR ULTRASOUND IMAGING OF CORONARY ARTERY IN CHILDREN AFTER KAWASAKI DISEASE:ASSESSMENT OF WALL MORPHOLOGY IN REGRESSED CORONARY ANEURYSMS AND ANGIOGRAPHICALLY NORMAL CORONARY ARTERY
- 学齢期以後の傍膜性部心室中隔欠損における自然閉鎖
- The relationship between the pharmacokinetics of a new antipsychotic, aripiprazole, and CYP2D6 genetic polymorphism in healthy adult volunteers
- Influence of Itraconazole Co-administration and CYP2D6 Genotype on the Pharmacokinetics of the New Antipsychotic ARIPIPRAZOLE
- Nonlinear Mixed Effects Model Analysis of the Pharmacokinetics of Aripiprazole in Healthy Japanese Males(Biopharmacy)
- Myocardial Ischemia in Kawasaki Disease Evaluation by Dipyridamole Stress Thallium-201 (Tl-201) Myocardial Imaging and Exercise Stress Test.