A Patient with Paget's Disease of Bone Treated with Etidronate Disodium.
スポンサーリンク
概要
- 論文の詳細を見る
A 69-year-old Japanese woman was referred to our hospital because of abnormal skull X-ray findings. Serum total alkaline phosphatase, bone-specific alkaline phosphatase 3, osteocalcin and propeptide carboxyterminal of type I procollagen (PICP) levels were markedly elevated. Urinary excretion of hydroxyproline was also increased, suggesting that both bone formation and resorption were accelerated. Radiography of the skull showed "cotton wool" appearance. TI-enhanced MRI revealed that the skull-cap and diploe were swelled up. In <SUP>99m</SUP>Tc-MDP bone scintigraphy, all areas of the skull and a part of the right hemipelvis showed high uptake of the radioisotope. Based on the findings we made diagnosis of Paget's disease of bone which is a rare bone disorder in Japanese. Three-month oral administration of etidronate disodium resulted in normalization of serum PICP levels and urinary hydroxyproline excretion, whereas alkaline phosphatase levels were only partially lowered. Levels of the markers of bone turnover remained normal during a follow-up period of 3 months after the discontinuation of the treatment.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
-
Nonaka Kyohei
Division Of Endocrinology And Metabolism Department Of Medicine Kurume University School Of Medicine
-
Yamada Kentaro
Division Of Endocrinology And Metabolism Department Of Medicine Kurume University
-
KAWASAKI KOICHI
Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine
-
KOGA KOHACHIRO
Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine
-
KOHNO SHUSUKE
Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine
-
ITOH TOSHIICHI
Itoh Clinic
関連論文
- Variations in the FTO gene are associated with severe obesity in the Japanese
- Mutation of RET Proto-Oncogene in Japanese Patients with Multiple Endocrine Neoplasia Type 2B and Sporadic Medullary Thyroid Carcinoma
- Interleukin-12B Gene Polymorphism does not Confer Susceptibility to Graves' Ophthalmopathy in Japanese Population
- Clinical characteristics of thyroid abnormalities induced by sunitinib treatment in Japanese patients with renal cell carcinoma
- Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography
- Genetic variations in the CYP17A1 and NT5C2 genes are associated with a reduction in visceral and subcutaneous fat areas in Japanese women
- Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area
- Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population
- Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population
- Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population
- Screening of 336 single-nucleotide polymorphisms in 85 obesity-related genes revealed McKusick-Kaufman syndrome gene variants are associated with metabolic syndrome
- Long-term efficacy of sitagliptin for the treatment of type 2 diabetic patients in Japan
- Increased prevalence of diabetic complications in Japanese patients with type 1 diabetes and nonalcoholic fatty liver disease
- Autoimmune Hypophysitis Treated with Intravenous Glucocorticoid Therapy
- A Patient with Paget's Disease of Bone Treated with Etidronate Disodium.
- Modulation by adiponectin of circadian clock rhythmicity in model mice for metabolic syndrome
- NUDT3 rs 206936 is associated with body mass index in obese Japanese women
- Long-term efficacy of sitagliptin for the treatment of type 2 diabetic patients in Japan