腦循環の化學的調節にかんする研究
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概要
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1) The correlation between the cerebral blood flow (CBF), measured by the N2O technique, and arterial chemical factors was studied in 38 normotensive healthy men.Studies made during normal respiration showed that an increase in CBF accompanied an increase in either the arterial CO2 content or the CO2 tension (PCO2), while the CBF decreased in proportion to any increase in the pH.However, the correlation between CBF and the arterial O2 content or tension (PO2) was not statistically significant.The study indicates that there are variations in the CBF in the various states of respiration, these depending chiefly on the PCO2.2) Loading tests were performed under various conditions, and the following observations were made; Inhalation of 5% CO2 in healthy men produced respiratory acidosis accompanied by a rise of PCO2, and as a result, CBF increased remarkably. Inhalation of 10% O2 (anoxia) produced a rise in the CBF.A drop in the CBF occurred after inhalation of 100% O2. Changes in the CBF occur when PO2 exceeds the normal values.3) A comparison of cerebral vascular response among hypertensives, apoplectics with residual hemiplegia, and healthy men showed a similar response in both hypertensives and healthy subjects; but an impaired cerebral vascular response in hemiplegics.4) In metabolic alkalosis a rise in the CBF was observed after the intravenous injection of 7% Sod. bicarbonate. However, there was a remarkable drop in CBF in metabolic acidosis after electric shock therapy. Thus, acidosis and alkalosis in respiratory and metabolic states affect the CBF in different fashions. This indicates that the correlation botween the arterial CO2 content and the CBF is positive.
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