副腎皮質内分泌の神經体液性調節に關する研究内臟神經電氣刺激による副腎靜脈血中17-hydroxy-corticosteroids (Nelson-Samuels法) の變動並びに副腎靜脈血流量に及ぼす二, 三の因子の影響
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1) Since several years ago, we have emphasized the existence of “Splanchnico-adrenocortical system”, besides “Hypophyso-adrenocortical system”. In order to confirm this theory, the following study was performed.In parallel with the estimation of the arterial blood pressure and adrenal blood flow (adrenal venous canulation and drop counter method), 17-OHCS levels (the modified Nelson-Samuels method) were determined in the dog adrenal venous blood under various experimental conditions.2) Corticoid output increased definitely during or immediately after the faradisation of the splanchnic nerve.It was confirmed that the splanchnic faradisation exerted the direct stimulative effect on the adreno-cortical function. Although the adrenal blood flow usually increased following the splanchnic faradisation, such an increased adrenal flow were not always accompanied by the increased corticoid output.Increased blood flow is regarded as the sum of the excitatory effects of all the vasomotors in the splanchnic nerve.3) By the foradisation of the vagal nerve no effects were observed on the adrenal blood flow nor on the corticoid output.4) Single intravenous ACTH increased adrenal blood flow remarkably, without significant elevation of the blood pressure.Its mechanism was discussed.Corticoid secretion was not enhanced by intravenous ACTH under surgical stress.5) Adrenal cortex appears to have the regulatory mechanisms to maintain corticoid secretion level under the considerable fluctuation of the adrenal flow. When the flow reduces extremely, tremendous increase of corticoid concentration was observed.
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