腎疾患患者並びに高血圧症患者の臨床像と腎生檢像に關する研究
スポンサーリンク
概要
- 論文の詳細を見る
A comparative study was made on the clinical picture of the kidney, its functions as revealed on renal clearance, and its histological picture disclosed on renal biopsy, in 93 cases of renal disease and hypertension, with these results obtained:(1) Clinical and histological pictures compared:There was a serious change or changes produced in the histological picture of the kidneys in most of those cases where the urine contained protein at concentrations of 5‰ or more, the maximum specific gravity of the urine did not exceed 1014, the systolic pressure was 175mm/Hg or more, the retinal finding was III degree or higher Keith-Wagener, or an abnormal ECG was given.The histological change of the kidney was greatly varied in severity-very slight in some cases, far advanced in others, and so on-in those cases in which the clinical symptoms were less serious than those manifested in the former cases.(2) Clearance and histological findings compared: The change produced in the histological picture of the kidneys was slight or moderate in the majority, and serious in some few of those cases where sodium thiosulfate clearance (Cthio) was 55cc/min. or more and sodium paraaminohippurate clearance (CPAH) 400cc/min. or more.In cases where the rate was 54-25cc/min. for the former clealance and 399-150cc/min. for the latter, a large variety of the histological changes-slight in some cases, and severe, in others and so forth-was seen occurring in the kidneys.In cases where the rate was 24cc/min. or less for the former and 149cc/min. for the latter, the histological change occurring in the kidneys was severe in most cases and mild or moderate in a few.It was thus seen in cases of renal disease and hypertension that the clinical condition related to the kidneys or the efficiency of the renal function was reflected in the histological picture of the organ in those of the cases where those clinical condition was far advanced severe or the renal functions were found seriously damaged on renal function tests.But the clinical condition related to the kidneys or the efficiency of the renal function was seldom or never reflected in its histological picture in those of the cases in which those clinical condition or its function was not damaged or mildly or moderately damaged.I hope that the result of this study will be of some clinical use in disclosing any possible histological change of the kidney in patients under diagnosis or treatment for renal disease and hypertension.
- 社団法人 日本内科学会の論文