肝障害時に於ける諸臓器組織内の蛋白質,残余窒素類の復旧速度と食餌性因子の影響に就いて
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概要
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Investigations have been made on the influences of diet factors on the recovering speed of liver insufficiency. Rabbits with experimental liver insufficiency are used in this study. Non-protein nitrogen, etc. (non-protein nitrogen, urinary nitrogen, amino-nitrogen, residualnitrogen, polypeptids, etc.) in various organs recover to the normal values within four to five weeks when the animals are fed with ordinary diet. It takes six to seven weeks, however, if the animals are given high fat diet, and some do not recover even after seven or eight weeks when fed with high carbohydrate diet. On the other hand, many will recover in three to four weeks when fed with high protein diet. It takes two, or three weeks more for protein in organs to recover to the normal. Analysis of free amino-acid in various organs has been done by means of paperchromatography. When the quantity of free amino-acid increases remarkably in two to three days right after the insufficiency, the kinds of amino-acid which appear in liver, kidney and muscle become also remarkably many. The increased amino-acids decrease after one or two weeks, and the kinds of amino-acid lessen to the normal as the total quantity of amino nitrogen decreases to the normal. These findings are marked in rabbits fed with high fat diet and equivocal in those fed with high protein diet. Therefore, we can say that the change of protein and its decomposed products is least and recovers most rapidly when high protein diet is given.
- 社団法人 日本内科学会の論文