肺結核患者におけるABO式血液型の凝集原價
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概要
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The agglutinogen titer of the erythrocyte was estimated in pulmonary tuberculosis patients and the healthy, and was investigated as to the relation to the grade of tuberculosis or to each sign of tuberculosis.The A-blood group serum as the agglutinin against the B-agglutinogen was obtained from a fixed healthy man normal in x-photo and blood sedimentation rate and positive in tuberculin reaction. The same was the case with the B-blood group serum. These standard sera were used for the agglutination reaction immediately after their preparation. The old sera were not used.The erythrocyte suspension of the patients to be tested was prepared by centrifuging their citrate blood and then by washing the obtained erythrocyte three times with a buffer.This suspension was dropped by one drop into a series of the gradually diluted solutions of the standard serum mentioned above, respectively. The agglutination was observed after 2 hours lapsed in an incubator.Thus, the agglutinogen titer was measured in 178 A-blood group patients, 150 B-group ones and 45 AB-group ones, and in 88 A-group healthy bodies, 59 B-group ones and 25 AB-group ones.In the A-and AB-blood groups, the A-agglutinogen titer under 25 was found more in incidence in the tuberculous than in the healthy. In the B-blood group, the B-agglutinogen titer under 25 or 27 was also found more in incidence in the tuberculous. But there was no distribution difference of the B-agglutinogen titer in the AB-blood group between the tuberculous and the healthy.Generally speaking, the agglutinogen titer in any blood group in lower in the tuberculous than in the healthy.Considering the blood sedimentation rate, x-photo, tubercle bacillus in sputum or gastric juice and complication, the patients were divided into three categories, namely the slight, moderate and severe. In the B-blood group, the B-agglutinogen titer under 25 was found the most in incidence in the severe category, and more in the moderate and less in the slight.It is well known that the serum of the tuberculous patients is abnormal. It, for instance, contains the antibody against tuberculosis, but it is not so discussed about the abnormality of the erythrocyte in tuberculosis. According to my experiment, the erythrocyte is as abnormal as to the agglutinogen titer as the serum as to the antibody in pulmonary tuberculosis.
- 社団法人 日本内科学会の論文