血球のCo-Carboxylase生合成と諸疾患との関係について

概要

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1) Differences are observed between the species of animals on the biosynthesis of Co-C (cocarboxylase) in blood corpuscles. The ability was very strong in rats and dogs, moderate in rabbits and relatively weak in guinea pigs and human being.2) The author then attempted to estimate the ability of biosynthesis of Co-C in blood corpuscles in various diseases. The results can be summarized as follows:a) In beriberi the content of Co-C in blood naturally decreased, but the conversion of added thiamine to Co-C was vivid. Also in some cases of pulmonary tuberculosis and in diabetes mellitus Co-C was decreased, and the biosynthesis of Co-C in blood corpuscles well maintained.b) In Basedow's disease no decrease of Co-C was observed and the biosynthesis of Co-C in blood corpuscles took place as usual.c) In hepatic diseases the Co-C index in blood generally did not differ from that in healthy people, except in liver cirrhosis in which the content of Co-C distinctly diminished in blood. As for the biosynthseis of Co-C in blood corpuscles, however, the ability apparently decreased fast in all cases of hepatic diseases.d) In malignant tumors the circumstances were very complicated.In certain cases the content of Co-C in blood diminished (perhaps due to anemia), but in other cases much increased.The biosynthesis of Co-C in blood corpuscles also was disturbed in some cases.
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