不完全抗体による溶血性貧血に関する研究
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概要
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Direct Coombs test was performed on the total of 157 cases with various kinds of hemal disease and allied illness. In consequence of this experiment, 30 out of 157 cases showed positive reaction; 13 out of 62 cases of chronic splenomegalia of unknown origin including so called Banti's syndrome, 1 out of 3 cases of chronic lymphogeneous leukemia, 1 out of 3 of acute myelogeneous leukemia, 2 out of 7 cases of panmyelopathia, a case of chronic erythroblastphthisis, 1 out of 2 of pernicious anemia, 2 cases of constitutional hemolytic anemia, 3 out of 7 cases of Laennec type of liver cirrhosis, 1 out of 6 cases of acute hepatitis, 1 out of 19 cases of typhoid fever (including paratyphoid), 2 out of 13 cases of other infectious disease, 2 out of 6 cases of cancerous disease. But the following cases showed negative reaction. They were 3 cases of chronic myelogeneous leukemia, 3 cases of reticulosarcomatosis, 3 cases of essential thrombccytopenia, 8 cases of Schönlein-Henoch's purpura and 7 miscellaneous diseases.It was suggested that the incomplete antibody is present on the patients who were suffering from various disease. But, the tendency of increasing hemolysis was not always observed, even on the Coombs test positive patients.It was observed with much interest that on the two cases of panmyelopathia and on a case of chronic erythroblastphthisis Coombs test revealed a positive reaction at the start and subsequently it changed to negative, and on a case of pernicious anemia incomplete antibody was not recognized during spontaneous remission.On a case of constitutional hemolytic anemia, antibody was proved 13 years after splenectomy.Furthermore, on a case with incomplete antibody for erythrocytes the presence of incomplete antibody for thrombocytes was also confirmed by the direct method, and on another two cases the presence of it was conceived with sufficient grounds.
- 社団法人 日本内科学会の論文