肝硬變症の研究白鼠に於ける脂肪性肝硬變の發生とその治療

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1. Albino rats were fed a choline-deficient diet for 8 months. Some of the rats were then killed and the remaining animals were fed the therapeutic diet containing 30% of casein and 40% mg of choline chloride for 6 months. Microscopic examination and quantitaive determinations of liver fat, liver collagen and serum protein were carried out on these animals.2. The livers of the rats fed the choline-deficient diet were finely granular, and microscopic examination showed fatty metamorphosis, ceroid accumulation, and fibrosis of the liver which began in the non-portal area. Receiving the dietary treatment fat disappeared rapidly, but there was no recognizable effect on fibrosis and ceroid accumulation.3. Liver fat increased remarkably on the choline-deficient diet, and returned to nearly normal level on the therapeutic diet. In the rats fed the choline-deficient diet for more than 18 weeks liver fat decreased as fibrosis or ceroid accumulation progressed.4. Liver collagen increased on the Choline-deficient diet, but did not seem to decrease after the treatment.5. On the choline-deficient diet serum albumin and albumin globulin ratio decreased markedly, but the increase of γ-globulin is not significant statistically. Reciving the dietary treatment albumin returned to narmal and γ-globulin increased significantly. Albumin globulin ratio increased significantly, but did not return to normal level.
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