血液凝固に關する研究 : 第1編 血小板の作用について
スポンサーリンク
概要
- 論文の詳細を見る
Factors taking part in blood coagulation in platelet extracts produced from oxalated human plasma, and effects of several drugs on the number of platelets and no the function of the platelet extracts were studied. And the comparison of the resistance of platelet against distilled water between patients with hemophilia and idiopathic thrombocytopenic purpura (ITP) and normal subjects was performed.The followings were the conclusion arrived.(1) Platelet extract possesses the thromboplastin activity, labile factorlike activity, the accelerating activity of the conversion of fibrinogen to fibrin and the activity of plasma thromboplastin activation, and all the above activities except the activation of plasma thromboplastin are destroyed by heating at 60°C for 20 minutes.(2) The thromboplastin activity of normal subjects is equivalent to 320 to 5120 times dilution of rabbit brain thromboplastin. With ITP it is reduced, and by blood transfusion or splenectomy it will regain normal level. The thromboplastin activity of platelet extracts with hemophilia is of similar with normal. There is no difference with other diseases.(3) The thromboplastin activity is reduced in the platelet extracts stored in an ice-box at 0°C.(4) Variation of the thromboplastin activity of platelet extracts is independent of the number of platelets.(5) Labile factor-like activity of platelet extracts of normal individuals is equivalent to 40 times dilution of labile factor in plasma. Labile factor-like activities of platelet extracts with ITP and aplastic anemia appear to be less than normal.(6) ACTH and cortisone increase the number of platelets. Their effects are conspicuous in thrombocytopenia with splenomegaly, and an increase of the number of platelets enhances the thromboplastin activity of platelet extract.(7) As to the resistance of platelet against distilled water, the one of hemophilia is stronger than of normal. In a case of ITP, it is weaker than the normal subject.
- 社団法人 日本内科学会の論文
著者
関連論文
- SF-066-2 インドシアニングリーンを用いた術中グラフト造影による新たなグラフト開存指標の開発(心臓2,サージカルフォーラム,第109回日本外科学会定期学術集会)
- 司会のことば (全身性疾患と造血障害)
- 血小板と血液凝固 (血液の凝固と臨床(シンポジウム))
- 血液凝固に関する研究-2-
- 血液凝固に関する研究-1-
- 司会のことば
- (4)血小板と血液凝固
- 血液凝固に關する研究 : 第2編 血漿および血清中のトロンボプラスチン形成因子について
- 血液凝固に關する研究 : 第1編 血小板の作用について
- 片側肥大症に発生した手根管症候群の1例