THE MODE OF THE CHANGE IN INTERNAL POTASSIUM OF THE FROG SARTORIUS MUSCLE PRODUCED BY THE CHANGE IN EXTERNAL POTASSIUM OR CALCIUM ION CONCENTRATION

スポンサーリンク

概要

• 論文の詳細を見る

• Using isolated frog sartorius muscles, tracer experiments and chemical analysis for K<SUP>+</SUP> and Na<SUP>+</SUP> were performed to evaluate the mode that the removal of external K<SUP>+</SUP> or Ca<SUP>++</SUP> affects on the change in internal K concentration.1. During the continuous depolarization of the muscle membrane, K<SUP>42</SUP> efflux was increased continuously while Ca<SUP>45</SUP> efflux was increased transiently. Although the changes in K or Ca efflux showed a parallelism with the change in membrane potential it is reasonable to suppose that the vacancy of the Ca<SUP>++</SUP> or K<SUP>+</SUP> sites of the membrane due to the withdrawal of external Ca<SUP>++</SUP> or K<SUP>+</SUP> is the first step of the change in internal K under these conditions.2. The exchange between ions of the same species takes place, at the membrane, more preferentially than the interchange between an ion and ions of different species. The K<SUP>+</SUP>-K<SUP>+</SUP> exchange in Ringer is not qualitatively different from the K<SUP>+</SUP>-Na<SUP>+</SUP> interchange in K free Ringer, because these two processes are capable of translating from each other by the condition which is determined by the ionic composition on both sides of the membrane.3. By repetitive stimulation, Na increase within the muscle occurred at the cost of K release in Ringer. This efflux of K<SUP>+</SUP> is different in nature from the net efflux of K<SUP>+</SUP> in K free Ringer. Accordingly, the K ions movable outwards are the adjuster for maintaining the constancy of internal milieu.4. The influence of the removal of external K<SUP>+</SUP> or Ca<SUP>++</SUP> upon the internal K loss takes place by different means. Detail of each process has been interpreted by the change in the pattern of association/dissociation of K or Ca ions with/from the membrane anionic sites.5. Removal of external K or Ca ions first produces the change in the membrane molecular configuration. Then, external K<SUP>+</SUP> influences upon internal K energetically through homogeneous K pool while Ca<SUP>+</SUP> does informationally through heterogeneous pools of K, Ca or both.

• 久留米大学医学部 The Kurume Medical Journal 編集部の論文

著者

• Noda K.

  Department of Obstetrics and Gynecology Kinki University school of Medicine

• TERASAKI S.

  Department of Physiology, Kurume University School of Medicine

関連論文

• IS-38 Correction of CDDP resistance in Mismatch Repair Deficient Cells by Chromosome Transfer
• EFFECTS OF OPERATIONAL CONDITIONS ON DRYING CHARACTERISTICS IN SUPERHEATED STEAM FLUIDIZED BED DRYING
• ON THE INTERACTION OF OUTFLOWING K IONS AND EXTERNAL Na IONS IN THE MEMBRANE OF SARTORIUS MUSCLE FIBERS OF FROGS
• ON THE MEMBRANE PROPERTY OF FROG SARTORIUS MUSCLE IN POTASSIUM RICH MEDIUM
• THE MODE OF THE CHANGE IN INTERNAL POTASSIUM OF THE FROG SARTORIUS MUSCLE PRODUCED BY THE CHANGE IN EXTERNAL POTASSIUM OR CALCIUM ION CONCENTRATION

スポンサーリンク