STUDIES ON THE ANTIGENICITY OF METABOLITES OF THE CANINE FILARIAE IN URINE
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概要
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An antigenic substance originated from the helminthic parasite appearing in the urine of infected host has been reported by Welt (1941), from his studies on Trichinella spiralis. Welt observed, during his experiment on monkeys artificially infected with Trichinella spiralis, that antigen was excreted into the urine of the monkeys several weeks after antibody had been produced in their sera . Subsequently, Okabe and Tanaka (1961) and Okabe and Ono (1961) discovered that an antigenic substance was transferred to the urine of a human patient infected with Schistosoma japonicum, and asserted that this fact had an important significance in the clinical diagnosis of schistosomiasis japonica. Furthermore, Okabe and his associates detected antigenic substances in the urine of human patients infected with liver and lung flukes, and reported the results of application of these substances to the clinical diagnosis of the respective diseases.It is difficult to collect adult worms of Wuchereria bancrofti for material in the preparation of antigen. Currently, an antigenic substance is extracted from adult worms of Dirofilaria immitis, instead of Wuchereria bancrofti, and used for the immunological diagnosis of the human filariasis.Should any antigenic substance originating from Wuchereria bancrofti appear in the urine of a human patient and be isolated from the urine, it will be a useful material for the immunological diagnosis of Wuchereria infection. Thus, a study on the urine of dogs infected with Dirofilaria immitis, was undertaken. It was confirmed that an antigenic substance, presumably derived from this filaria, had been excreted into the urine of the dogs. Furthermore, this substance was isolated, purified, and examined for biological and immunological properties. The results of the study are reported in the present paper.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文