EXPERIMENTAL HEAVY METAL POISONINGS WITH SPECIAL REFERENCE TO CERTAIN LIVER FUNCTION TESTS
スポンサーリンク
概要
- 論文の詳細を見る
It has been well documented that certain chemicals are injurious to the liver, and such impairments are detectible by blood analyses. However, most of these studies were primarily concerned with liver damage and little effort has been made to differentiate other organ damages which accompany the poisoning. Moreover, these studies were aimed at producing parenchymatous necrosis irrespective of the properties of chemicals employed. Neither has there been any established rule which correlates the nature of damage and chemical property. Advancing industrialization has given rise to rapidly increasing accidents associated with the use of various chemicals, organic or inorganic. In medicine, a number of heavy metals are used in the form of drugs some of which have been known to be poisonous in spite of their therapeutic effects. This study was designed to elucidate chemical changes of blood produced by certain heavy metals commonly in use in medicine and industry from the point of view of liver damage, and to ascertain whether or not liver damage could be assessed in the presence of other organ damages, perticulary the kidney. Because of an ever increasing list of liver function tests, the present study concentrated on serum proteins and transaminase. Complement was also included in view of the fact that this protein behaves in a special manner in some diseased states and because of the sporadic reports suggesting its value in certain liver damages. For comparison, an organic hepatotoxic compound, chlorpromazine was used.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文