ACIDIC POLYSACCHARIDES IN CANCER

概要

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In a previous paper (1960) the authors reported that a mixture of equal quantities of hexosamine and hexuronic acid was most effective for preventing the occurrence of experimental hepatic cancer of rat induced by oral administration of p-dimethylaminoazobenzene (DAB), compared to mixtures of another component of acid mucopolysaccharide (AMPS). The fact has thereafter made the authors interested in relationship between cancer and AMPS. On the other hand, it is presumed that AMPS is always found in the inflammatory focus of the injured tissue perhaps as a defense responses of the body and is possible to combine with basic substances as histamine and peptide produced by the abnormal breakdown of inflammatory tissue protein. These may suggest that AMPS not only compose the substrate of connective tissue but also has a role of preventing the growth of canceric tissues or neutrizing toxic substances produced by malignant tissue elements.Thus, an attempt was made in this paper to examine such possibilities by investigating detailed properties of each AMPS fraction (hyaluronic acid, chondroitin sulfuric acid, heparin and the like), of constituents soluble in physiologic saline solution, and of serum protein fractions, esp. the basic fractions, found in the tissue and blood of human well as experimental cancer.
久留米大学医学部 The Kurume Medical Journal 編集部の論文