Immunoelectron microscopic study of IgA deposition in livers of patients with chronic liver diseases.

概要

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In order to clarify the significance of IgA of patients with chronic liver disease, the IgA deposition along the hepatic sinusoids was studied by immunoelectron microscopy. By light microscopy, two diferent staining patterns of IgA were recognized: linear and granular. The former was pathognomonic to alcoholics, and the latter was frequently observed with chronic agressive hepatitis.<BR>By immunoelectron microscopy, the linear pattern corresponded to the diffuse reaction deposition in the cytoplasmic matrix of sinusoidal endothelial cells, and the granular pattern corresponded to the round granular reaction products in the same cells.<BR>The double staining method revealed that the localization of IgA is different from lysozyme or endogenous peroxidase activity.<BR>These results suggest in the chronic liver cell damage, IgA and reticulo-endothelial system are closely connected.
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