Studies on the stimulating function of peripheral blood monocyte against T cell blastogenesis and the activity of suppressor macrophages in patients with chronic liver diseases.

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The stimulating function of peripheral blood monocytes against T cell blastogenesis in patients with chronic liver disease was investigated by measuring its stimulating role on T cell blastogenesis to PHA. Stimulating role of monocytes against T cell blastogenesis in patients with chronic active hepatitis (CAH), chronic hepatitis with sublobular hepatic necrosis (CHcSN) and liver cirrhosis (LC) were decreased, compared with control subjects (p<0.05, p<0.01, p<0.01). In order to eluciate the cause of monocytes hypofunction, the activity of suppressor macrophages was examined. Its activity in patients with CIcSN and LC was markedly enhanced compared with control subjects (p<0.05, p<0.05). It was suggested that suppressor macrophages played a role on monocyte hypofunction. Corticosteroid was proved to suppress the stimulating role of monocytes, but did not suppress suppressor macrophages. It was suggested that monocyte and macrophage participated in dysfunction of cellular immunity in chronic liver diseases.
社団法人日本肝臓学会の論文