Clinical significance of the circulating concentration of HBeAg and its subfraction in chronic hepatitis B virus carriers.

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概要

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• Clicical significance of circulating concentration of HBeAg and its subfraction precipitated at 36.5% saturation with ammonium sulfate (IgG-bound "large" HBeAg) was studied in HBeAg positive chronic HBV carriers. Serum HBeAg concentration was measured by enzyme immunoassay using monoclonal antibodies to HBeAg. Serum HBeAg concentration was significantlyhigher in asymptomatic HBV carriers (AsC) than in patients with chronic liver diseases (CLD). The ratio of large HBeAg in sera of AsC was significantly lower than in those of patients with CLD. Furthermore in AsC, HBeAg concentration decreased and the ratio of large HBeAg increased prominently with the development of acute liver injury. The sequential changes of HBeAg concentration ran in parallel with those of HBV specific DNA-polymerase activity in interferon treated cases, though with some time difference. These results indicate that quantitative assay of HBeAg and its subfraction can be useful for the evaluation of the stage and prognosis of chronic HBV infection.

• 社団法人 日本肝臓学会の論文

著者

• 和田 秀一

  信州大学医学部第2内科

• 和田 秀一

  信州大学医学部第2内科学教室

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• Clinical significance of the circulating concentration of HBeAg and its subfraction in chronic hepatitis B virus carriers.

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