Peripheral blood lymphocyte subsets in primary biliary cirrhosis.
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Lymphocyte subsets of peripheral blood of patients with primary biliary cirrhosis (PBC) were investigated by flow cytometry using various monoclonal antibodies. The fluorescence intensity of OKT11+ cells was increased specifically in PBC, but it was decreased during azathioprine administration in a case of PBC. Moreover, the fluorescence intensity of OKT11+ cells was also increased by PHA stimulation to lymphocytes from normal subjects. The percentage of DR+·Leu12- cells was significantly increased, in PBC as compared to normal controls, and in symptomatic PBC as compared to asymptomatic PBC. These findings suggest that activated T
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- Peripheral blood lymphocyte subsets in primary biliary cirrhosis.