Pathological study on hepatocellular carcinoma - A study of histological changes after transcatheter arterial embolization.:A study of histological changes after transcatheter arterial embolization
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The pathological changes in hepatocellular carcinoma (HCC) treated with transcatheter arterial embolization (TAE) were investigated in 21 autopsy cases and 13 surgical cases at the 1st pathological department of Kurume University Hospital during the recent 36 months. 24 autopsy and 9 surgical cases without TAE and one-shot injection chemotherapy were studied as a control. 28 autopsy and 7 surgical cases treated with one-shot injection chemotherapy were also studied comparatively.<BR>The results were as follows;<BR>1. The average survival time of 21 autopsy cases treated with TAE was 9.9 months, and comparative figure for a control group was 2.9 months with a stastical significance (t-test p<0.01). However, there was no significant difference between the cases treated with TAE or one-shot injection chemotherapy.<BR>2. The average rate of necrosis in the tumor among the cases treated with TAE was higher than that of controls. Higher incidence of tumor necrosis among the cases treated with TAE was recognized in encapsulated HCC than replacing and sinusoidal HCCs. The rate of necrosis of tumor thrombus with the portal vein of the cases treated with TAE was not different from that of controls.<BR>3. Histologically, it was suspected that encapsulated or replacing type might transform sinusoidal type following several times of TAE treatments.<BR>4. The incidence of appearance of xanthoma cell around tumor necrosis in the cases treated with TAE was higher than that of controls.<BR>5. Although in the cases treated with TAE, the hepatic arteries showed intimal thickening, stenosis, and thrombus formation in varying degrees.<BR>The frequency of these findings was not significantly different from that of the cases treated with one-shot injection chemotherapy.
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- Pathological study on hepatocellular carcinoma - A study of histological changes after transcatheter arterial embolization.:A study of histological changes after transcatheter arterial embolization