Clinical evaluation of brain edema and monitoring of intracranial pressure in patients with fulminant hepatitis.

概要

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Intracranial pressure (ICP) and findings of CT-Scan and EEG were evaluated in 10 cases with fulminant hepatitis. Results were as follows; 1) Initial ICP level in 10 cases was ranged between 10 and 28mmHg and ICP level was exceeded over 20mmHg in cases with Grade IV or V encephalopathy. 2) Maximal ICP level was significantly higher in fatal cases. 3) Duration from the day developing encephalopathy to the day showing maximal ICP level was significantly shorter in survival cases; 3.8 ± 1.3 (M ± SD) days in survival cases versus 6.0±1.4 days in fatal cases. 4) ICP and EEG were valuable for the evaluation of brain edema. 5) ICP should be monitored at Grade III encephalopathy. 6) When ICP is not monitored, administration of mannitol should be started at the stage of Grade IV encephalopathy.
社団法人日本肝臓学会の論文