EXPERIMENTAL STUDY ON THE DEVELOPMENT OF CORONARY ARTERIOSCLEROSIS

概要

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Male rabbits and dogs, divided into 19 groups (Table 1, 2) were fed during one to three months to determine the effect of the disturbed lipid metabolism, hypertension and of the injury in intima, on the development of experimental coronary lesions:1) Fatty deposition in the intima of coronary arteries were dbserved only in the animals with the hypercholesteremia, but no significant relationship could be established between the elevation of the total plasma cholesterol, lipoprotein index, lipid phosphorus ratio, and the incidence of coronary lesions.2) There was no doubt about the fact that this experimentally produced hypertension remarkably increased the incidence of the lesions, but there was no significant correlation between the presence of hypertension and the development of lesions.3) In all 19 groups, histopathological findings of coronary lesions were intimal thickening, the more acid mucopolysaccharide was found in the less fibrosed wall and the less in the more fibrosed wall, and the primary change of coronary lesion was progressive fibrotic degradation of the acid mucopolysaccharide.4) In conclusion, various forms of intimal injuries may play the primary roll in the development of vascular lesions, while the factors such as the disturbance of lipid metabolism and the elevation of arterial pressure enhance it secondarily.
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