THE STUDY ON CHOLINESTERASE-ACTIVITY IN MYASTHENIA OCULARIS:THE EFFECT OF PROSTIGMIN, D. F. P. AND PAROTIS HORMON
スポンサーリンク
概要
- 論文の詳細を見る
The author have seen 10 cases of myasthenia ocularis originally named by Tanobe, to be measured cholinesterase-activity in plasma and red cell by electrometric method and observed the change of cholinesterase-activity by the administration of prostigmin, D. F. P., and parotis hormon compared with the palpebral aperture, and obtained the following results.(1) The cholinesterase-activity in serum of all cases were excessive than normal average.(2) After administration of prostigmin serum cholinesterase-activity were markedly below than those of the value before administration and palpebral aperture were enlarged.(3) After administration of D. F. P. cholinesterase-activity in serum were impeded about 50 to 60 per cent, and cholinesterase in red cells were also slightly impeded, but no clinical improvement was appeared.(4) The author assumed that the fault in myasthenia ocularis may be due to a decreased formation of acetylcholine at myoneural junction, the existence of some abnormal substance in the blood which has a curarelike action, a destructive action for acetylcholine synthesis, and also due to relative decrease of cholinacetylase to be reciprocal with cholinesterase.Finally the author expresses his sincere thanks to Prof. M. Uemura, Assistant Prof. K. Katow, and Instructor K. Kawashima for continuous guidance and encouragement.
- The Keio Journal of Medicineの論文