THE BIOCHEMICAL STUDIES ON PIGMENTARY DEGENERATION OF RETINA:RETINITIS PIGMENTOSA
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概要
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The author carried out several experiments upon the biochemistry in pigmentary degeneration of the retina (P.D.R.) and the present paper is concerned with the experiments on the liver function, lipid metabolism, and lipoprotein-mucoprotein metabolism.The results were summarized as follows.1. The various colloidal reactions in P.D.R. resembled those of liver disease, but the grades of positivities were comparatively lower than those of liver disease. In the experiments on the liver function of P.D.R., it was assumed that latent liver functional disorders could be found in this disease.2. Both the concentration of total cholesterol and phospholipid in the serum remains statistically in normal average, and the fraction of esterified cholesterol were not decreased. Cholesterol-Phospholipid ratio(C/P) were lower than those of normal person. Then, the author noted that liver functional disorders in P.D.R. may not be evident but latent, and phospholipid may be comparatively increased in the serum to cholesterol. It is assumed that abnormal amount of lipid may be stored particularly in the cells of the central nervous system.3. Both alpha- and beta-lipoprotein were in normal concentration, and ratio of beta- to alpha-lipoprotein were also normal.4. It is thought that, the tapetoretinal degeneration including P.D.R. are due to faulty metabolism of fat with the resulting deposition of lipid in the cells of the central nervous system. P.D.R. is the late juvenile form of the tapetoretinal degeneration without dementia, then the author proved that this disease was one of the groups of degenerative diseases, and obviously associated with the abnormal lipid storage, and might be a disease of miscel-laneous disorders of lipid metabolism with tapetoretinal degeneration, and upon a wide construction it might be a kind of latent lipoidosis in thesaurimosis.Finally the author expresses his sincere thanks to Prof. M. Uyemura, Assistant Prof. Y. Kuwabara, Instructor K. Katow and Instructor K. Kawashima for continuous guidance and encouragement. And the author hereby convey to Dr. Saitow, Dr. Ozawa, and Dr. Numao my hearty thanks for the encouragement and the cooperation they gave me on this study.
- The Keio Journal of Medicineの論文