RELATIONSHIP BETWEEN IN VITRO SENSITIVITY TO A TISSUE POLYPEPTIDE AND VIRULENCE FOR MICE OF SALMONELLA ENTERITIDIS
スポンサーリンク
概要
- 論文の詳細を見る
A basic polypeptide was extracted from calf thymus which exerted the inhibition on the oxygen consumption and the growth in a semisynthetic medium of Salmonella enteritidis.A close correlation between the sensitivity of the organisms to the growth-inhibitory action of the polypeptide and their virulence for mice was found. The decrease in virulence during aged broth culture of a highly virulent strain of S. enteritidis was more closely correlated with the change in sensitivity to the polypeptide than with S-R mutation processes. However, no increase of virulence was accompanied when sensitive strains acquired in vitro a high resistance to the polypeptide.In the culture medium in which the growth-inhibitory action of the polypeptide is measured, the concentration of NaCl added was found to be critical in order to predict the difference in virulence of organisms tested.We are greatly indebted to the late Dr. B. Kitasato for his valuable help in the present study.
- The Keio Journal of Medicineの論文
著者
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OHASHI TOSHIHIKO
Department of Bacteriology, School of Medicine, Keio University
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USHIBA DAIZO
Department of Bacteriology, School of Medicine, Keio University
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HIGUCHI SABURO
Department of Bacteriology, School of Medicine, Keio University
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USHIBA DAIZO
Department of Bacteriiology, School of Medicine Keio University
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