STUDIES ON INFLUENCE OF THE MODERATE DOSE PICROTOXIN UPON THE BODY TEMPERATURE AND THE BLOOD OSMOTIC PRESSURE IN RABBITS
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1. Subcutaneous injection of the moderate dose picrotoxin would lower the body temperature of unfastened rabbits at normal room temperature. The fall of the body temperature due to the injection of the drug should be induced by stimulation of the drug on the parasympathetic body temperature regulating centers in the narrow sense, for it would not be caused in such rabbits as, of which the body temperature has been already lowered under 37°C by fastening of them, as which have been situated at hot environment, as of which vagal nerves has been bilaterally cut off, as in which antipyrine has been previously injected, as of which hepatic arteries has been ligated.2. Influence of subcutaneous injection of the moderate dose picrotoxin on the blood osmotic pressure in rabbits would depend on the fact whether their body temperature is lowered or not by it.The blood osmotic pressure would be increased when the body temperature is lowered by it as in unfastened rabbits at normal room temperature, while it would be decreased when the body temperature is not lowered by it as in fastened rabbits of which the body temperature has been already lowered under 37°C or as in unfastened rabbits at hot environment.Then the increase of the blood osmotic pressure due to the injection of the moderate dose picrotoxin should have correlation with the fall of the body temperature caused by the injection of the drug.3. But the increase of the blood osmotic pressure due to the injection of the moderate dose picrotoxin should be caused not only by the fall of the body temperature induced by it but also by increase of the epinephrine internal secretion of the adrenal glands, which would be induced by stimulation of the drug on the parasympathetic splanchnic nervous centers which are also located in the brain where is supplied by the blood flowing through the internal carotid arteries.Then the increase of the blood osmotic pressure due to the injection of the drug should be induced mostly by excitation of the sympathetic blood osmotic pressure regulating centers due to the fall of the body temperature caused by the injection of the drug, but partially by stimulation of the drug on the parasympathetic splanchnic nervous centers which would promote the epinephrine internal secretion of the adrenal glands.4. The decrease of the blood osmotic pressure due to the injection of the drug should be caused by stimulation of the drug on parasympathetic blood osmotic pressure regulating centers, for it could be prevented by ligation of the internal carotid arteries and also by vagotomization in rabbits.5. By subcutaneous injection of the moderate dose picrotoxin the blood osmotic pressure should be changed in the three ways, as above mentioned. Above all the increase of the blood osmotic pressure caused by excitation of the sympathetic blood osmotic pressure regulating centers due to the fall of the body temperature would be however induced most powerfully. And the increase of it due to increase of the epinephrine internal secretion of the adrenal glands caused by stimulation of the drug on the parasympathetic splanchnic centers would be induced weaker than the decrease of it due to stimulation of the drug on the parasympathetic blood osmotic pressure regulating centers.This is the reason why the blood osmotic pressure would be increased significantly in unfastened rabbits at normal room temperature as their body temperature is lowered by the injection of the drug, while it would be decreased in fastened rabbits of the low body temperature or in unfastened rabbits at hot environment as their body temperature is not lowered by the injection of it and it would be increased slightly in bilaterally vagotomized rabbits at normal room temperature as their body temperature is not lowered and their blood osmotic pressure is not decreased by the injection of it.
- The Keio Journal of Medicineの論文
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- STUDIES ON INFLUENCE OF THE MODERATE DOSE PICROTOXIN UPON THE BODY TEMPERATURE AND THE BLOOD OSMOTIC PRESSURE IN RABBITS