HLA class I defects in malignant lesions : What have we learned?

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概要

• 論文の詳細を見る

• Depending on the tumor types, HLA class I antigen downregulation or loss has been found in 16% to 50% of malignant lesions in many malignancies with a clinical association with histopathological markers of poor prognosis of the disease and with reduced free interval and survival. These findings may reflect the escape of tumor cells with HLA class I abnormalities from recognition and destruction by HLA class I-restricted, tumor-associated antigen-specific cytotoxic T lymphocytes. This possibility has stimulated investigations on the mechanisms underlying HLA class I antigen abnormalities in malignant cells. Distinct molecular defects underlying an abnormal HLA class I phenotype have been identified and characterized. These defects range from structural alterations of the genes which encode HLA class I antigen subunits to deregulation of antigen processing machinery components responsible for a functional HLA class I antigen expression. These findings, in conjunction with those of clinical recurrence of lesions with HLA class I antigen loss following T cell-based immunotherapy in patients, suggests that immunoselection may play a role in the generation of malignant lesions with HLA class I antigen abnormalities. This possibility has stressed the need to effectively monitor functional HLA class I antigen expression in malignant lesions in the application of T cell-based immunotherapy as well as to develop strategies to circumvent the negative impact of immunoselection.

• The Keio Journal of Medicineの論文
• 2003-12-01

著者

• FERRONE Soldano

  Department of Immunology, Roswell Park Cancer Institute

• CHANG Chien-Chung

  Department of Microbiology and Immunology, Chang Gung University College of Medicine

• Ferrone Soldano

  Department Of Immunology Roswell Park Cancer Institute

• Chang Chien-chung

  Department Of Immunology Roswell Park Cancer Institute

• CAMPOLI Michael

  Department of Immunology, Roswell Park Cancer Institute

• Campoli Michael

  Department Of Immunology Roswell Park Cancer Institute

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• HLA class I defects in malignant lesions : What have we learned?

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