Arteriovenous shunting blood flow is intravitally observed in the stomach after thermal injury in rats
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概要
- 論文の詳細を見る
Microcirculatory disturbance of the gastric wall is a crucial factor in the development of gastric mucosal lesions induced by Helicobacter pylori, anti-inflammatory drugs and stress. Opening of the arteriovenous shunting channel after thermal injury is one of the possible mechanisms to reduce mucosal blood flow. However, no in vivo observation of arteriovenous shunting blood flow in the stomach has been reported. To assess gastric microcirculatory disturbance, especially arteriovenous shunting blood flow after thermal injury by in vivo microsciopy, male Wistar rats were anesthetized and thermal injury was inflicted on the back skin. Gastric microvascular images were observed by in vivo microscopy. Rolling of leukocytes labelled with carboxyfluorescein diacetate, succinimidyl ester were counted and blood flow dynamics were observed by flow of a micro dye, monastral blue B (MBB). The endothelial damage was assessed by deposits of MBB 5 min after the administration. Arteriovenous shunting blood flow is difficult to detect by normal methods, but it could be observed by flow of MBB after thermal injury. Statistical analysis showed a significant difference in the ratio of arteriovenous shunting blood flow detection between the control (no injury) (0%;n=15) and thermal injury (5 hrs after thermal injury) (28.6%;n=14) groups. In the thermal injury group, the percentage of rolling leukocytes and the area of monastral blue B deposits increased, and the venular walls tended to be irregular. The total length of erosion increased time-dependently after thermal injury, and the length at 5 hrs was approximately 2 times larger than that at 2 hrs. Arteriovenous shunting blood flow is intravitally observed after thermal injury. A-V shunting blood flow can be a cause of mucosal hypo-perfusion. It is suggested that the microcirculatory disturbance seen 5 hrs after thermal injury is con-tributed to the final step of erosion formation.
- The Keio Journal of Medicineの論文
- 2002-12-01
著者
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KITAJIMA Masaki
Department of Surgery, Keio University School of Medicine
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Yoshida Masashi
Department of Cardiology, Hiroshima City Hospital
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OTANI YOSHIHIDE
Department of Surgery, Keio University School of Medicine
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KUBOTA TETSURO
Department of Surgery, Keio University School of Medicine
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WAKABAYASHI GO
Department of Surgery, Keio University School of Medicine
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ISHIKAWA Hideki
Department of Emergency and Critical Care Medicine School of Medicine, Keio University
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SHIMAZU Motohide
Department of Surgery, School of Medicine, Keio University
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KAWACHI Shigeyuki
Department of Surgery, School of Medicine, Keio University
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Tanabe Minoru
Department Of Pediatric Surgery Keio University School Of Medicine
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Tanabe Minoru
慶応義塾大学 医学部小児外科
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Kitajima Masaki
栃木県立がんセンター研究所 がん遺伝子研究室
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Yoshida Masashi
国際医療福祉大学附属三田病院 消化器センター
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Otani Yoshihide
Department Of Gastroenterological Surgery International Medical Center Saitama Medical University In
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Kubota Tetsuro
Center For Comprehensive And Advanced Medicine Keio University Hospital
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Otani Y
Department Of Gastroenterological Surgery International Medical Center Saitama Medical University In
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Seno M
Department Of Bioscience And Biotechnology Faculty Of Engineering Graduate School Of Natural Science
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Kubota Tetsuro
Department Of Surgery Keio University
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Kitajima Masaki
Department Of Surgery
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Ishikawa Hideki
Department Of Emergency And Critical Care Medicine School Of Medicine Keio University
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Ishikawa Hideki
Department Of Canccr Epidemiology Research Institute Osaka Medical Center For Cancer And Cardiovascu
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Kawachi Shigeyuki
Department Of Surgery Keio University School Of Medicine
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Wakabayashi Go
Department Of Surgery Iwate Medical University School Of Medicine
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Wakabayashi Go
Department Of Surgery Iwate Medical University
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Morikawa Yasuhide
Department Of Pediatric Surgery Keio University School Of Medicine
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Shimazu Motohide
Department Of Surgery Keio University School Of Medicine
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Yano M
Fruit Tree Res. Station Ministry Of Agriculture Forest And Fishery Shizuoka
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Kitajima Masaki
Departmemt Of Surgery Keio University School Of Medicine
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Matsumoto Yoichi
Department Of Surgery Keio University School Of Medicine
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Matsumoto Yoichi
Department Of Pediatric Surgery Keio University School Of Medicine
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Yoshida Masashi
Department Of Agricultural Biochemistry And Biotechnology Tottori University
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Shinoda Masahiro
Department Of Surgery School Of Medicine Keio University
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Seno Masaharu
Department of Surgery, Keio University School of Medicine
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