Oncogene expression in the liver tissue of patients with various liver disease.
スポンサーリンク
概要
- 論文の詳細を見る
We examined the expression of nine cellular oncogenes in liver samples from seventy patients with various liver disease. With c-K-ras, four RNA bands (5.6-, 2.1-, 1.5-, and 1.2-kilobase RNA species) were detected in all the liver tissue examined without significant variation in the relative intensities of the bands. Expression of c-fos was also detected in the human liver tissue, but its expression level was very low. Expression of other oncogenes was not detected.<BR>Our results indicate that (1) there may be little correlation between liver regeneration in the human liver disease and the expression of oncogenes examined; (2) the constant expression of c-K-ras in the human liver may be linked to essential hepatocellular function rather than carcinogenesis. The significance of c-K-ras expression in the human liver remains to be determined.
- 社団法人 日本肝臓学会の論文