A histochemical study of .GAMMA.-GTP of patients with hepatitis or cirrhosis. A comparison of serum .GAMMA.-GTP and isozyme patterns.:A comparison of serum γ-GTP and isozyme patterns
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A study was made a comparison of a histochemical examininations of γ-GTP, serum γ-GTP and isoenzyme Pattems. In zymograms, most of cases with GT<SUB>2</SUB> (comparable to fraction of α<SUB>2</SUB>-globulin) and GT<SUB>3</SUB> (that of β-globulin) were found in patients of chronic active hepatitis (C.A.H.) and liver cirrhosis (L.C.).<BR>A marked activity of this enzyme was ohserved in swollen of Kupffer cells in cases of acute hepatitis, while that in hepatic lobules and marked proliferation of bile ductules in C.A.H. and L.C.. As the results of correlation between γ-GTP activity in liver cells·bile canaliculi and the epithelium of bile ducts and serum γ-GTP isoenzyme patterns, augmetation of GT<SUB>3</SUB> fraction was found in cases with the increase γ-GTP activity of that, significantly more increasing than GT<SUB>1</SUB> and GT<SUB>2</SUB> fractions. Furthermore, most of cases with GT<SUB>3</SUB> fraction were patients of C.A.H. or L.C., <BR>It is reasonable to presume that the pregress ef liver damage may causes the increase of serum γ-GTP and γ-GTP activity in the liver, moreover GT<SUB>3</SUB> ffaction was accompanied with the increasing of γ-GTP activity in liver cell·bile canaliculi and the epithelium of bile ducts.