下行性胆道感染の発生機序に関する実験的研究

概要

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The mechanism of ascending infection of biliary tract from the intestinal canal has been generally accepted. However, the possibility of the descending infection through the portal system has also been conjectured. The present study was designed to confirm whether the possibility of the mechanism of descending infection in the biliary tract through the portal system is really present or not. As the experimental animals Wister strain rats were used and E. coli in various consentrations were injected from portal vein, then, culture of drained bile, and histological study of the liver were carried out. The results obtained are as follows: In bacteriological study E. coli was detected in the bile, 7 hours after injection of the bacteria only when 1×108 was injected into the portal vein. In the light and electron microscopic studies, E. coli was found in the Kupffer cell, Disse's space and in the liver cell. The destruction of liver cells and inflammatory cell reaction caused micro-abscesses in the liver, which might result in invasion of E. coli from the portal vein to the biliary tract.
社団法人日本肝臓学会の論文