Long-term follow-up study of liver histology in alcoholic liver disease.

概要

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In 101 alcoholic patients performed serial liver biopsies at the intervals of more than six months, histological changes of the liver were examined and the factors that affected those changes were studied. In patients who stopped drinking (40 cases), histological improvement was seen in 45.7% and the histologically progressed cases (9 cases) had significantly high incidence of the history of blood transfusion, drug addict and/or viral hepatitis. In patients who continued drinking (61 cases), histological deterioration was seen in patients with the history of longer and larger amount of alcohol consumption. In patients who showed the histology of chronic hepatitis, the abstained case with inactive chronic hepatitis was improved to hepatic fibrosis, but the case with active chronic hepatitis developed to liver cirrhosis at the high incidence. In patients with serum antibody to alcohol altered hepatocyte plasma membrane, the histological deterioration after alcohol consumption was observed in a short period and higher incidence compared with patients with no antibody. Therefore, mode of alcohol intake, infection of NANB hepatitis virus and association with the antibody to alcohol altered hepatocyte plasma membrane play an important role in the histological development of alcoholic liver disease.
社団法人日本肝臓学会の論文