肝の過形成性病変と門脈圧亢進に関する病理形態学的検討

概要

論文の詳細を見る
Nodular lesions in the liver with idiopathic portal hypertension (IPH) were observed in 14 out of 40 autopsy cases (35%), and in 4 out of 51 surgical cases (7.8%). We examined the following 11 cases, classifying into two groups; portal hypertensive group (8 cases) and non-portal hypertensive group (3 cases). 4 cases with IPH prominent nodular lesions, 6 cases with nodular regenerative hyperplasia (NRH) and 1 case with partial nodular transformation (PNT). The results were as follows; 1. Portal hypertensive group showed the decreased liver weight, the increased spleen weight and the histological findings including scarring of the peripheral portal vein, portal sclerosis and abnormal pathway.<BR>As to the relationship between portal hypertension and the nodule (hyperplasia of the hepatocytes), it was likely that the nodule might secondarily develop in association with the pathogenesis which lead to portal hypertension. The following reasons were cited; 1. Multiple nodular transformations were found in NRH without portal hypertension. 2. The nodular formation of various degree was found in IPH. 3. The collapse of the peripheral portal vein was also found in NRH and PNT.
社団法人日本肝臓学会の論文