Clinicopathologic study on 23 resected cases of focal nodular hyperplasia.

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Twenty-five nodules of focal nodular hyperplasia (FNH) from 23 patients were studied clinicopathologically. Male to female ratio was 1:0.53, and the mean age was about 49 years old. Among 6 cases in whom ultrasound-guided fine-needle aspiration biopsy was performed, 4 cases were misdiagnosed as "well-differentiated hepatocellular carcinoma", and only 2 cases were properly diagnosed as "FNH". "Central scar" (stellate fibrosis), which is one of the characteristic feature of FNH was seen even in 3 minute nodules out of 5 less than 1 cm in diameter. FNH nodules without a distinct central scar accounted for about 30% of all the nodules. There were 3 nodules with capsule formation, 4 nodules with liver cell dysplasia and 14 nodules with fatty change. Chronic hepatitis was associated in two cases. Hemangioma-like lesion surrounded by zonal hyperplasia of hepatocyte in the vicinity of FNH nodule seen in one case suggested the possibility of focal vascular abnormality as the pathogenesis of FNH.
社団法人日本肝臓学会の論文