HBc抗体測定導入後に発症した輸血後B型劇症肝炎の1例

概要

論文の詳細を見る
A 65-year-old man who had admitted to our hospital due to Alzheimer disease received blood transfusion because of hematemesis and tarry stool from gastric ulcer. Three months later after blood transfusion, he consulted was with complaints of jaundice, impaired consciousness and fever, and was diagnosed as fulminant hepatitis B. He died of hepatic failure without effects of treatments. One donor of 21 blood transfused was demonstrated to be HB virus carrier afterwards. The donor's serum revealed that HBs antigen was negative by RPHA (reversed passive hemagglutination) but positive by EIA, HBs antibody was positive and HBc antibody was high-titered (28-29) by HI (hemagglutination inhibition) method. Since November 1989, Japanese Red Cross Blood Centers sceened donors for high-titer(≥26) antibody to Hepatitis B core antigen in the absence of HBs antigen and antibody. Since then no post-transfusion heptitis B case has been reported, except one case whom transfused from a primary infected donor of hepatitis B virus without detectable anti-HBc antibody. Our case is the first case of post-transfusion hepatitis B receiving a healthy HB carrier's blood in Japan after screening for anti-HBc antibody.
社団法人日本肝臓学会の論文