The mechanism of elevated plasma endothelin-1 levels in CCl4-treated rats.

スポンサーリンク

概要

• 論文の詳細を見る

• To investigate the mechanism of elevated plasma endothelin-1 (ET-1) levels in patients with liver cirrhosis, ET-1 levels were measured both in inferior vena cava (IVC) and portal vein (PV) in rats carrying acute liver injury (AI) and liver fibrosis (LF) experimentally induced by CCl<SUB>4</SUB>. There was a little difference in ET-1 levels between IVC and PV in LF, whereas ET-1 levels in IVC were significantly lower than those in PV in control. In AI, ET-1 levels of IVC and PV were both significantly elevated than those in control. The administration of prostaglandin E<SUB>1</SUB> derivative slightly elevated ET-1 levels in PV while it markedly lowered ET-1 levels in IVC. These results indicate that liver is the site of ET-1 degradation and the poor clearance of ET-1 is the reason of the elevation of plasma ET-1 levels in patients with liver cirrhosis.

• 社団法人 日本肝臓学会の論文

著者

• 内田 靖

  島根医科大学第2内科

関連論文

• Duck hepatitis B virus を用いた Ara-A の抗ウイルス効果の検討
• ヘパドナウイルスの感染様式に及ぼす参三七と猪苓多糖の影響 : アヒルB型肝炎ウイルスを用いた検討
• The mechanism of elevated plasma endothelin-1 levels in CCl4-treated rats.
• Serum pancreatic phospholipase A 2 value of liver disease patient whom it measured using monoclonal antibody and its clinical significance.

スポンサーリンク