Change of HCV-RNA in liver tissue and interferon responsiveness in patients with chronic hepatitis C.

概要

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In order to clarify the relationship between the change of HCV-RNA in liver tissue and response to IFN therapy, HCV-RNA in sera and liver tissues of 30 patients with chronic hepatitis C were examined before and after IFN therapy. Before therapy, serum HCV-RNA were detected in 29 out of 30 (96.7%) patients, and liver tissues of all 14 patients examined were positive for HCV-RNA. At the end of IFN therapy, serum HCV-RNA was still positive in 6 (20%) patients and liver tissues of 11 (36.7%) patients contained HCV-RNA. Comparison of HCV-RNA levels in liver tissues of 13 patients before and after IFN therapy revealed that the viral titers decreased following therapy in all cases except one. As for the relationship between the change of HCV-RNA presence and the therapeutic effect, relapse was observed in all the patients who had been positive for HCV-RNA in liver tissue at the end of IFN therapy. Even among 18 patients who were negative for HCV-RNA in both serum and liver tissue, only 8 (44%) patients showed an excellent response to IFN therapy. These results indicate that the relapse is observed in all of those patients in whom HCV-RNA became negative in serum but was still positive in liver tissue at the end of therapy, and that there are also some cases who show relapse even after disappearance of HCV-RNA from liver tissue.
社団法人日本肝臓学会の論文