潜在性肝性脳症の診断-脳波mapping,聴覚誘発電位の検討

概要

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Psychometric tests (WAIS-R), topographical analysis of cerebral electrical activity (brain mapping) and auditory brain stem reaction (ABR) were applied to 22 patients in liver cirrhosis without overt hepatic encephalopathy and 15 healthy controls to clarify the incidence of subclinical hepatic encephalopathy (SHE). WAIS-R results were abnormal in 18 subjects (82%), brain mapping in 20 subjects (91%), and ABR in 14 subjects (64%). WAIS-R, brain mapping, ABR were significantly correlated to blood ammonia levels and portosystemic shunt. These data suggested that the incidence of SHE is high in liver cirrhosis without overt hepatic encephalopathy. WAIS-R, brain mapping and ABR were sensitive indexes of SHE. Furthermore, the degree of SHE may appear to be related to the degree of portosystemic hepatic shunt.
社団法人日本肝臓学会の論文