無麻酔,無拘束下における犬の脳波記録法--特に肝性脳症研究への応用

概要

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We established a novel method to record canine electroencephalogram (EEG) under non-anesthesia and non-restraint condition, and applied to the studies of hepatic encephalopathy (H.E.). Beagles were trained every day laying quietly in a sealed box for not less than 2 hours for 2 weeks. The trained beagles were undertaken portcaval anastomosis operation (PCA), and their EEGs were recorded every day at fixed time. Slow wave appeared stably and dominantly within one month after PCA. In accordance with the changes in their EEGs, characteristic changes similar to patients with H.E. in blood chemistry and aminograms were observed. The deteriorated EEGs were normarized rapidly by the infusion of amino acid solution a specifically formulated for liver failure (THF), and this beneficial effect was retained even one hour after the end of the infusion. Those results suggest that the novel method may be useful for evaluating the effects of amino acid infusions on canine normal or abnormal EEGs.
社団法人日本肝臓学会の論文