ヒト肝癌のヌ-ドマウスへの移植に関する研究--可移植系の樹立とその性格
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Successful heterotransplantation was reported for 6 out of 15 human liver cancers from 14 patients. They were consecutively transplanted to the nude mice. Among of them, one hepatocarcinoma (Hc-4) has been serially transplanted 12 passages with 100% take rate. The tumors began to grow on the nude mice 10 days after transplantation and increased in size semilogalithm-liniarly. The doubling time was 5 days. The tumor volume was 300-600 mm<SUP>3</SUP> after 4 weeks. Alpha-fetoprotein was detected in the sera of almost of the mice.<BR>The histological characteristics of the original tumors was well maintained in the transplanted tumors. However, the alveolar pattern was not manifest due to decrease in the stroma. The tumor (Hc-4) was identified as a tumor of the human origin with the absorption test, Ouchterlony's method and the chromosomal analysis.<BR>Hc-4 tumor seems to be useful for studying tumor biology and various therapeutic modalities for hepatoma.
- 社団法人 日本肝臓学会の論文
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- ヒト肝癌のヌ-ドマウスへの移植に関する研究--可移植系の樹立とその性格
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